💊 CIAMED – Human Labs: Tadalafil Dosage Overview

Tadalafil, best known under the trade name Cialis (Lilly Pharma), is a
PDE-5 inhibitor developed for the treatment of
erectile dysfunction (ED).
Since 2010, it has also been approved for pulmonary arterial hypertension (PAH) and since 2012 for benign prostatic hyperplasia (BPH).
The unique characteristic of Tadalafil is its long half-life of approximately 17.5 hours, which allows effects to last up to 36 hours (DrugBank DB00820).

📌 Recommended Tadalafil Dosage

• Erectile Dysfunction (ED):
  • 10–20 mg taken before sexual activity.
  • For daily use, 5 mg once daily allows for spontaneous sexual activity (Cialis 5 mg leaflet).
• Pulmonary Arterial Hypertension (Adcirca®):
  • 40 mg once daily (usually as 2 x 20 mg tablets).
  (Medknowledge Adcirca)
• Benign Prostatic Hyperplasia (BPH):
  • 5 mg once daily, improving urinary flow and reducing prostate-related symptoms
  (Pharmazeutische Zeitung).

⏳ Pharmacokinetics

Tadalafil’s onset of action is usually about 30–60 minutes after ingestion.
Its long half-life (≈ 17.5 h) distinguishes it from other PDE-5 inhibitors like Sildenafil and Vardenafil, allowing up to 36 hours of effect (PubChem 110635).

⚠️ Safety & Contraindications

• ❌ Do not combine with organic nitrates or NO-donors (e.g. Poppers) – risk of life-threatening hypotension (Lilly Fachinformation).
• ❌ Contraindicated in severe cardiovascular disease, recent myocardial infarction, or arrhythmias.
• ❌ Avoid in severe renal or liver impairment.

💡 Possible Side Effects

Common: headache, indigestion, nasal congestion, back pain.
Rare but serious: priapism, sudden hearing loss, or cardiovascular events.
(EMA Public Report)