LETROMED – Human Labs

💊 Letrozole for Fertility – LETROMED Human Labs

Letrozole is a non-steroidal aromatase inhibitor that lowers estrogen levels by blocking the enzyme aromatase.
While approved as a breast cancer treatment in postmenopausal women (PharmaWiki), it is also widely prescribed off-label for fertility treatment – especially in women with ovulation disorders such as PCOS.

⚕️ How Letrozole Helps Fertility

By reducing estrogen levels, letrozole increases the release of FSH (follicle-stimulating hormone), which stimulates ovulation.
This mechanism makes it an alternative to clomiphene for women who do not respond to standard fertility treatments.

📈 Medical Use & Dosage

• Standard medical use: treatment of hormone-sensitive breast cancer in postmenopausal women
• Off-label use: fertility treatment to induce ovulation
• Typical dosage: once daily tablet at the same time, independent of meals (PharmaWiki)

⚠️ Side Effects & Risks

Side effects are mainly due to reduced estrogen levels:

• 🔥 Hot flashes & sweating
• 🦴 Joint pain
• 💤 Fatigue & weakness
• ⬆️ Hypercholesterolemia
• 🚫 Contraindications: pregnancy, breastfeeding, premenopausal women

❌ Misuse Warning

Letrozole is sometimes misused as a doping agent in bodybuilding to reduce estrogen.
Such use is banned in and outside competitions and carries health risks.

📚 References & Sources

• PharmaWiki – Letrozol
• Dellapasqua S., Colleoni M. Letrozole. Expert Opin Drug Metab Toxicol, 2010
• Keating G.M. Letrozole in hormone-responsive breast cancer. Drugs, 2009
• Smith I.E., Dowsett M. Aromatase inhibitors in breast cancer. NEJM, 2003