💊 CLOMED – Human Labs: Clomiphene Citrate for Men

Clomifene (Clomiphene) is a selective estrogen receptor modulator (SERM), originally approved in 1967 for the treatment of female infertility (Drugs.com Monograph, MedlinePlus).
In men, it is used off-label to restore natural testosterone production and support fertility, especially in cases of male hypogonadism.

⚡ How Clomiphene Works in Men

Clomiphene blocks estrogen receptors in the hypothalamus, reducing negative estrogen feedback.
This stimulates the release of GnRH and subsequently LH and FSH from the pituitary gland, leading to increased testosterone production and spermatogenesis (PubChem CID 2800).

📌 Medical & Performance Uses

• Male Hypogonadism: Increases testosterone 2–2.5× in men with low baseline levels (Study).
• Fertility Restoration: Supports spermatogenesis and is used as an alternative to testosterone replacement (MedlinePlus).
• Post-Cycle Therapy (PCT): Popular in bodybuilding to restore natural hormone production after anabolic steroid use (not medically approved).

⚠️ Contraindications

Clomiphene should not be used in men with:

• ❌ Liver disease or history of hepatotoxicity
• ❌ Pituitary or testicular tumors
• ❌ Unexplained abnormal bleeding

It is also banned in professional sports by the World Anti-Doping Agency (WADA) under hormone modulators (S4).

💡 Side Effects

Common: hot flashes, headaches, mood swings, visual disturbances.
Rare but serious: hormonal imbalances, liver abnormalities, increased risk of certain cancers with long-term use (DrugBank DB00882).