PROVIRON 25 Para Pharma – Mesterolone (Proviron)

⚗️ Chemistry

Mesterolone is a DHT derivative with an additional methyl group at the 1α position.
This change increases oral activity and reduces liver strain.
In contrast to testosterone, mesterolone does not aromatize into estrogen.
Consequently, users avoid problems like water retention and gynecomastia.

🔬 Mechanism of Action

Proviron works as a pure androgen by binding to the androgen receptor.
However, enzymes in muscle tissue inactivate it quickly.
As a result, it shows only weak anabolic effects but strong androgenic and anti-estrogenic properties.

🧬 Pharmacology

The 1α-methylation improves oral bioavailability of proviron.
Moreover, it lowers liver toxicity compared to many other oral steroids.
It binds strongly to sex hormone-binding globulin (SHBG), freeing more active testosterone.
Therefore, doctors often prescribe it for androgen deficiency and bodybuilders value it for better androgen balance.

💊 Medical Uses of Mesterolone

Doctors prescribed Proviron for several conditions:

• Treatment of male hypogonadism (androgen deficiency)
• Improving fertility in men with oligospermia
• Supportive therapy in anemia caused by myelofibrosis

Today, some countries still allow its medical use, although others discontinued it.

⚠️ Side Effects

Users may experience several side effects:

• Acne and oily skin
• Changes in libido
• Aggression, irritability, or nervousness
• Increased red blood cell count
• Liver strain in rare cases
• Virilization in women (deep voice, hair growth)

Nevertheless, Proviron causes fewer liver problems than most oral steroids.

🏋️ Mesterolone Misuse in Bodybuilding

Bodybuilders often add Proviron to cutting cycles.
Because it reduces estrogen activity and raises free testosterone, it creates a leaner and harder look.
However, it provides little direct muscle growth and works mainly as a support compound in steroid stacks.

🚫 Legal Status

Mesterolone is a controlled substance in the US, UK, Germany and many other countries.
Consequently, you need a medical prescription to use it legally.
Moreover, the World Anti-Doping Agency (WADA) bans it in professional sports.

📚 References

• Wikipedia: Mesterolone
• PubChem: Mesterolone
• WADA – Prohibited List